Protein Details: Transient receptor potential channel mucolipin 3

Protein ID

ICDB_Pro_1304

Protein Name

Transient receptor potential channel mucolipin 3

Gene Name

Mcoln3

Organism

Mus musculus (Mouse)

Length

553 amino acids

AlphaFoldDB

AF-Q8R4F0-F1-model_v4.pdb

Function

Sequence

MANPEVLVSSCRARQDESPCTFHPSSSPSEQLLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSEVYDQIIFAVTQYLQLQNISVGNHAYENKGTKQSAMAICQHFYRQGTICPGNDTFDIDPEVETECFLVEPDEASHLGTPGENKLNLSLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIKECKDWHVSGSIQKNTHYMMIFDAFVILTCLASLVLCARSVIRGLQLQQEFVNFFLLHYKKEVSASDQMEFINGWYIMIIISDILTIVGSVLKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVMRFCCCAAMIYLGYCFCGWIVLGPYHEKFRSLNRVSECLFSLINGDDMFSTFAKMQQKSYLVWLFSRVYLYSFISLFIYMILSLFIALITDTYETIKHYQQDGFPETELRKFIAECKDLPNSGKYRLEDDPPGSLLCCCKK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in the cochlea; particularly in the inner and outer hair cells (at protein level)

DOI ID

10.1073/pnas.222425399; 10.1126/science.1112014; 10.1073/pnas.0709096104; 10.1073/pnas.0709846104; 10.1113/jphysiol.2008.156992; 10.1371/journal.pone.0014317; 10.1016/j.bbrc.2013.11.044

RefSeq

NP_598921.1; XP_006501144.1; XP_006501145.1; XP_006501146.1; XP_006501147.1;